کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3285955 | 1209252 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Histologic Spectrum of Nonalcoholic Fatty Liver Disease in Morbidly Obese Adolescents
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کلمات کلیدی
HOMA-IRNAFLDCCHMCNASHDLDBPSBPhigh-density lipoprotein - HDL یا لیپوپروتئین با دانسیته بالا یا چگالی بالاhomeostasis model assessment of insulin resistance - ارزیابی مدل هومیوستاز مقاومت به انسولینnonalcoholic steatohepatitis - استاتو هپاتیت غیر الکلیNonalcoholic fatty liver disease - بیماری کبدی چربی غیر الکلیbody mass index - شاخص توده بدنBMI - شاخص توده بدنیdiastolic blood pressure - فشار خون دیاستولیکsystolic blood pressure - فشار خون سیستولیکLow-density lipoprotein - لیپوپروتئین کم چگالی یا الدیال LDL - لیپوپروتئین کم چگالی(کلسترول بد)Cincinnati Children’s Hospital Medical Center - مرکز پزشکی بیمارستان سینسیناتیNonalcoholic fatty liver disease activity score - نمره فعالیت بیماری کبد چرب غیر الکلیNash - نوش
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Background & Aims: To characterize the spectrum of nonalcoholic fatty liver disease (NAFLD) in morbidly obese adolescents, we correlated liver histology with clinical features and compared findings with reported adult data. We hypothesized that NAFLD would be less severe as a result of younger age and shorter duration of obesity, but portal inflammation and fibrosis would be more prevalent. Methods: Cross-sectional study was made of 41 adolescent subjects, 13-19 years old (mean, 16 years), 61% female, 83% non-Hispanic white, mean body mass index 59 kg/m2, undergoing gastric bypass with liver biopsy. Liver biopsies were graded and staged as proposed by the NASH Clinical Research Network. Data were analyzed by using descriptive statistics, analysis of variance, and Fisher exact tests. Results: Eighty-three percent had NAFLD: 24% steatosis alone, 7% isolated fibrosis with steatosis, 32% nonspecific inflammation and steatosis, and 20% nonalcoholic steatohepatitis (NASH). Twenty-nine percent had fibrosis; none had cirrhosis. Abnormal ALT (P = .05) and AST (P = .01) were more prevalent in NASH. Mean fasting glucose was significantly higher in NASH (P = .05), but prevalence of the metabolic syndrome was not significantly different. Conclusions: NAFLD was very prevalent in morbidly obese adolescents, but severe NASH was uncommon. In contrast to morbidly obese adults, lobular inflammation, significant ballooning, and perisinusoidal fibrosis were rare, whereas portal inflammation and portal fibrosis were more prevalent, even in those who did not meet criteria for NASH. These findings might support use of a modified scoring system for pediatric NASH. Presence of the metabolic syndrome in morbidly obese adolescents did not distinguish NASH from steatosis alone.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Gastroenterology and Hepatology - Volume 4, Issue 2, February 2006, Pages 226-232
Journal: Clinical Gastroenterology and Hepatology - Volume 4, Issue 2, February 2006, Pages 226-232
نویسندگان
Stavra Xanthakos, Lili Miles, John Bucuvalas, Stephen Daniels, Victor Garcia, Thomas Inge,