کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3285980 | 1209254 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Diagnostic Value of C-Reactive Protein for Predicting Activity Level of Crohn's Disease
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کلمات کلیدی
PPVVHIIQRSPEROCpositive predictive value - ارزش پیش بینی مثبتnegative predictive value - ارزش پیش بینی منفیCrohn’s disease - بیماری کرونUpper limit of normal - حد بالای طبیعیSensitivity - حساسیتconfidence interval - فاصله اطمینانinterquartile range - محدوده بین محدبNPV یا negative predictive value - مقادیر پیش بینی شده منفیSpecificity - ویژگیC-reactive protein - پروتئین واکنشی سیCRP - پروتئین واکنشی سی یا سی. آر. پی receiver operating characteristic - گیرنده عامل عامل
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Diagnostic Value of C-Reactive Protein for Predicting Activity Level of Crohn's Disease Diagnostic Value of C-Reactive Protein for Predicting Activity Level of Crohn's Disease](/preview/png/3285980.png)
چکیده انگلیسی
Background & Aims: Measuring Crohn's disease (CD) activity is useful in clinical trials as well as in clinical practice, but each available instrument to measure such activity has some limitations. C-reactive protein (CRP) is a sensitive marker for inflammation and tissue injury. The aims of the study were: to assess the diagnostic value of low level of CRP for predicting a low CD activity, and to calculate optimal CRP cutoff value for selecting patients with moderate or high CD activity. Methods: One hundred fifty consecutive patients with active or nonactive CD were included in the study without any pre-selection criteria. CRP was measured, and CD activity was calculated by means of the van Hees index (VHI). Results: The median VHI score was 154.4 (interquartile range, 126.0-193.4), and the median CRP was 19.1 mg/L (interquartile range, 6.1-50.1 mg/L; upper limit of normal [N], 4 mg/L). Forty-nine percent of our patients had CRP >20 mg/L. CRP was significantly correlated to VHI (P = .0001). The probability that VHI was <150 if CRP was below upper limit of normal was equal to 1 (confidence interval, 0.891-1.000). The diagnostic value for CRP predicting a VHI â¥150 was high; the area under the receiver operating characteristic curve was equal to 0.844 (confidence interval, 0.783-0.906; P = .0001) with an optimal cutoff value of 21.6 mg/L, about 5 à N. Conclusions: CRP appears useful to evaluate CD activity, especially to predict inactive or low activity CD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Gastroenterology and Hepatology - Volume 4, Issue 7, July 2006, Pages 882-887
Journal: Clinical Gastroenterology and Hepatology - Volume 4, Issue 7, July 2006, Pages 882-887
نویسندگان
Patrick Chamouard, Zoe Richert, Nicolas Meyer, Gabriel Rahmi, René Baumann,