کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
329144 | 1433601 | 2011 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The polyunsaturated fatty acids, EPA and DPA exert a protective effect in the hippocampus of the aged rat
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The polyunsaturated fatty acids, EPA and DPA exert a protective effect in the hippocampus of the aged rat The polyunsaturated fatty acids, EPA and DPA exert a protective effect in the hippocampus of the aged rat](/preview/png/329144.png)
چکیده انگلیسی
Age is characterized by deficits in synaptic function identified by decreased performance of aged animals in spatial learning tasks and reduced ability of animals to sustain long term potentiation (LTP). Several cellular and molecular events are correlated with these deficits, many of which are indicative of age-related neuroinflammatory and oxidative cell stress. It is significant that agents which decrease microglial activation are commonly associated with restoration of function. We set out to examine whether the n-3 polyunsaturated fatty acid docosapentaenoic acid (DPA), which is a metabolite of eicosapentaenoic acid (EPA), could modulate the age-related increase in microglial activation and the associated increase in oxidative changes and therefore impact on synaptic function in aged rats. We demonstrate that docosapentaenoic acid possesses neurorestorative effects and is capable of downregulating microglial activation. The data show that it also decreases the coupled activation of sphingomyelinase and caspase 3, probably because of its ability to decrease age-related oxidative changes, and consequently attenuates the age-related decrease in spatial learning and long-term potentiation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 32, Issue 12, December 2011, Pages 2318.e1-2318.e15
Journal: Neurobiology of Aging - Volume 32, Issue 12, December 2011, Pages 2318.e1-2318.e15
نویسندگان
Laura Kelly, Belinda Grehan, Andrea Della Chiesa, Shane M. O'Mara, Eric Downer, George Sahyoun, Karen A. Massey, Anna Nicolaou, Marina A. Lynch,