کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3291954 1590038 2016 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes
ترجمه فارسی عنوان
پیوند دادن مکانیزم های بیماری زائی بیماری های کبدی الکلی با فنوتیپ های بالینی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
چکیده انگلیسی

Alcoholic liver disease (ALD) develops in approximately 20% of alcoholic patients, with a higher prevalence in females. ALD progression is marked by fatty liver and hepatocyte necrosis, as well as apoptosis, inflammation, regenerating nodules, fibrosis, and cirrhosis.1 ALD develops via a complex process involving parenchymal and nonparenchymal cells, as well as recruitment of other cell types to the liver in response to damage and inflammation. Hepatocytes are damaged by ethanol, via generation of reactive oxygen species and induction of endoplasmic reticulum stress and mitochondrial dysfunction. Hepatocyte cell death via apoptosis and necrosis are markers of ethanol-induced liver injury. We review the mechanisms by which alcohol injures hepatocytes and the response of hepatic sinusoidal cells to alcohol-induced injury. We also discuss how recent insights into the pathogenesis of ALD will affect the treatment and management of patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 150, Issue 8, June 2016, Pages 1756–1768
نویسندگان
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