کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3295565 | 1209857 | 2008 | 23 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Performance of Transient Elastography for the Staging of Liver Fibrosis: A Meta-Analysis
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کلمات کلیدی
PSCAUROCPBCSROCalcoholic steatohepatitis - استاتو هپاتیت الکلیnonalcoholic steatohepatitis - استاتو هپاتیت غیر الکلیAsh - خاکسترDANA - داناPrimary biliary cirrhosis - سیروز صفراوی اولیهbody mass index - شاخص توده بدنBMI - شاخص توده بدنیconfidence interval - فاصله اطمینانarea under the receiver operating characteristic curve - محدوده تحت منحنی مشخصه عملکرد گیرندهNash - نوشPrimary sclerosing cholangitis - کلانژیت اسکلروئیدی اولیهQUADAS - کواداس
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Background & Aims: Transient elastography has been studied in a multitude of liver diseases for the staging of liver fibrosis with variable results. A meta-analysis was performed to assess the overall performance of transient elastography for the diagnosis of liver fibrosis and to analyze factors influencing the diagnostic accuracy. Methods: Literature databases and international conference abstracts were searched. Inclusion criteria were as follows: evaluation of transient elastography, liver biopsy as reference, and assessment of the area under the receiver operating characteristic curve (AUROC). The meta-analysis was performed using the random-effects model for the AUROC, summary receiver operating curve techniques, as well as meta-regression approaches. Results: Fifty studies were included in the analysis. The mean AUROC for the diagnosis of significant fibrosis, severe fibrosis, and cirrhosis were 0.84 (95% confidence interval [CI], 0.82-0.86), 0.89 (95% CI, 0.88-0.91), and 0.94 (95% CI, 0.93-0.95), respectively. For the diagnosis of significant fibrosis a significant reduction of heterogeneity of the AUROC was found when differentiating between the underlying liver diseases (P < .001). Other factors influencing the AUROC were the scoring system used and the country in which the study was performed. Age, body mass index, and biopsy quality did not have a significant effect on the AUROC. Conclusions: Transient elastography can be performed with excellent diagnostic accuracy and independent of the underlying liver disease for the diagnosis of cirrhosis. However, for the diagnosis of significant fibrosis, a high variation of the AUROC was found that is dependent on the underlying liver disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 134, Issue 4, April 2008, Pages 960-974.e8
Journal: Gastroenterology - Volume 134, Issue 4, April 2008, Pages 960-974.e8
نویسندگان
Mireen Friedrich-Rust, Mei-Fang Ong, Swantje Martens, Christoph Sarrazin, Joerg Bojunga, Stefan Zeuzem, Eva Herrmann,