Loss of Lsc/p115 Protein Leads to Neuronal Hypoplasia in the Esophagus and an Achalasia-Like Phenotype in Mice

lsc/p115 deficiency results in impaired neuronal innervation and in motor dysfunction recapitulating several aspects of esophageal achalasia. Reduced expression of nerve growth factor and a reduced number of glia cells most likely contribute to this phenotype.