کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3297775 | 1209889 | 2006 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
High Prevalence and Mapping of Pre-S Deletion in Hepatitis B Virus Carriers With Progressive Liver Diseases
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کلمات کلیدی
BCPChronic carrierpHSAHCC - HCCamino acid - آمینو اسیدprecore - دقتCirrhosis - سیروزNucleotide - نوکلئوتیدHBV - هپاتیت بChronic hepatitis - هپاتیت مزمنhepatitis B virus - ویروس هپاتیت بیBasal core promoter - پروموتر هسته BasalHepatocellular carcinoma - کارسینوم هپاتوسلولار(کارسینوم سلولهای استخوانی)
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Background & Aims: The interactions among pre-S deletion, precore (PC) mutation, and basal core promoter (BCP) mutation in various stages of chronic hepatitis B virus (HBV) infection remain unclear and were thus investigated in this study. Methods: The sequences of the pre-S region and the BCP (A1762T, G1764A) and PC (G1896A) mutations were determined in 46 HBV chronic carriers (CC) and 106 age-matched carriers with different stages of liver diseases, including 38 chronic hepatitis (CH), 18 cirrhosis (LC), and 50 hepatocellular carcinoma (HCC). Results: A higher prevalence of pre-S deletion and BCP and PC mutations was found in carriers with progressive liver diseases compared with the CC group. By logistic regression analysis, patients with pre-S deletion and BCP mutation were significantly associated with the development of progressive liver diseases than those without. Combination of mutations rather than single mutation was associated with the development of progressive liver diseases, especially in combination with pre-S deletion. Sequencing analysis showed that the deleted regions were more often in the 3â² terminus of pre-S1 and the 5â² terminus of pre-S2. Further mapping of these pre-S deletion sequences found that all the deletion regions encompassed T- and B-cell epitopes, and most of them lost 1 or more functional sites. Conclusions: Our data indicate that patients with progressive liver diseases have a higher frequency of pre-S deletion.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 130, Issue 4, April 2006, Pages 1153-1168
Journal: Gastroenterology - Volume 130, Issue 4, April 2006, Pages 1153-1168
نویسندگان
Bing-Fang Chen, Chun-Jen Liu, Guey-Mei Jow, Pei-Jer Chen, Jia-Horng Kao, Ding-Shinn Chen,