کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3297917 | 1209891 | 2007 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: SOX9 Is Required for the Differentiation of Paneth Cells in the Intestinal Epithelium SOX9 Is Required for the Differentiation of Paneth Cells in the Intestinal Epithelium](/preview/png/3297917.png)
Background & Aims: The transcription factor SOX9 has been shown previously to have an essential role in the differentiation of a small number of discrete cell lineages. In the intestine, Sox9 is expressed in the epithelial cells of the crypts and is a target of Wnt signaling. Methods: To examine the function of SOX9 in the intestine, we inactivated the Sox9 gene in intestinal epithelial cells by generating mice that harbored a conditional Sox9 gene and a Villin-Cre transgene. Results: In the absence of SOX9, Paneth cells were not formed, but the differentiation of other intestinal epithelial cell types was unaffected. The lack of SOX9 also lead to crypt enlargement, to a marked increase in cell proliferation throughout the crypts, and to replacement of the Paneth cells by proliferating epithelial cells. Conclusions: We conclude that SOX9 is required for the differentiation of Paneth cells. Our results elucidate an essential step in the differentiation of gut epithelium.
Journal: Gastroenterology - Volume 133, Issue 2, August 2007, Pages 539–546