کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3297998 | 1209892 | 2006 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The Translation of Helicobacter pylori Basic Research to Patient Care
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کلمات کلیدی
NF-κBLPSTNFERKTLRMAPK - MAPKinterferon - اینترفرونIFN - اینترفرون هاinterleukin - اینترلوکینPAI - باباToll-like receptor - تیالآرPathogenicity island - جزیره پاتوژنیکFas Ligand - فاس لیگاندFasL - فاسدtumor necrosis factor - فاکتور نکروز تومورnuclear factor κB - فاکتور هسته ای κBlipopolysaccharide - لیپوپلی ساکاریدmajor histocompatibility complex - مجموعه سازگاری بافتی اصلیMHC - مجموعه سازگاری بافتی اصلیmitogen-activated protein kinase - پروتئین کیناز فعال با mitogenExtracellular signal–regulated kinase - کیناز تنظیم شده با سیگنال غیر سلولی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
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چکیده انگلیسی
In 1984, Barry Marshall and Robin Warren proposed a role for bacterial infections in the pathogenesis of gastroduodenal disease, which triggered an avalanche of research intended to prove or disprove their theory. The result has been a series of advances that have enhanced our understanding of these diseases and completely modernized the clinical approach to their management. In just over 20 years, many aspects of the immunopathogenesis of these diseases have been dissected at the molecular level, with key pathogenic mechanisms being validated by the identification of genes that are associated with the development of gastric cancer. There has been particular emphasis on understanding the molecular structures associated with Helicobacter pylori and their role in modifying the host responses. Gastric immune and inflammatory responses have emerged as key elements in the pathogenesis of gastritis and epithelial cell damage. This review summarizes important findings emanating from basic research primarily related to the immunopathogenesis of H pylori that have advanced the practice of medicine or our understanding of gastroduodenal disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 130, Issue 1, January 2006, Pages 188-206
Journal: Gastroenterology - Volume 130, Issue 1, January 2006, Pages 188-206
نویسندگان
Peter B. Ernst, David A. Peura, Sheila E. Crowe,