کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3299624 | 1209933 | 2006 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inactivation of Hepatic Microsomal Triglyceride Transfer Protein Protects Mice From Diet-Induced Gallstones
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کلمات کلیدی
HDLVLDLMTTPIDLhigh-density lipoprotein - HDL یا لیپوپروتئین با دانسیته بالا یا چگالی بالاapolipoprotein - آپولیپوپروتئینFree fatty acid - اسید چرب آزادintermediate density lipoproteins - لیپوپروتئین های چگالی متوسطvery-low-density lipoproteins - لیپوپروتئینهای با چگالی کمmicrosomal triglyceride transfer protein - پروتئین انتقال تری گلیسرید میکروسمالی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Background & Aims: Microsomal triglyceride transfer protein (MTTP) is critical for the production of very-low-density lipoproteins (VLDL). The current studies were undertaken to examine the in vivo role of MTTP in hepatic cholesterol and fatty acid metabolism, as well as in biliary lipid secretion. We also tested whether MTTP plays a role in diet-induced cholelithiasis in mice. Methods: We used mice in which Mttp had been inactivated in the liver (MttpÎ/Î mice). We measured several parameters of cholesterol metabolism, fatty acid synthesis, and biliary lipid levels in mice fed a normal or a lithogenic diet. We also assessed the incidence of diet-associated gallstones. Results: Hepatic Mttp inactivation markedly decreased plasma triglyceride and cholesterol levels and increased biliary cholesterol and bile acid output. Hepatic cholesterogenesis and fatty acid synthesis were significantly decreased in MttpÎ/Î mice compared with control mice. The incidence of gallstones decreased from 90% in control mice to 33% in MttpÎ/Î mice after 8 weeks of a lithogenic diet (P < .0001). The mechanism of the protective effect appears to be increased biliary phospholipid output in MttpÎ/Î mice, leading to significant unsaturation of gallbladder bile. Conclusions: These results indicate that modulation of Mttp expression in the liver affects hepatic lipid synthesis and storage as well as biliary lipid secretion. Our findings further indicate that inhibition of hepatic MTTP activity decreases the risk of experimental cholelithiasis by favoring phospholipid output into the bile.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 131, Issue 6, December 2006, Pages 1870-1878
Journal: Gastroenterology - Volume 131, Issue 6, December 2006, Pages 1870-1878
نویسندگان
Ludwig Amigo, Juan Castro, Juan Francisco Miquel, Silvana Zanlungo, Stepheng Young, Flavio Nervi,