Association study of the paraoxonase 1 gene with the risk of developing Alzheimer's disease

Recently, a region encompassing the promoter and intron 1 of the paraoxonase 1 gene (PON1) have been associated with the risk of developing Alzheimer's disease (AD) in a large pan-ethnic (Caucasian and African-American) dataset. We attempted to replicate this observation in a large French study of sporadic cases and controls. We confirmed that the proximal promoter and 5′ sequence of the PON1 gene may harbor unknown functional variant(s) associated with the risk of developing AD.