کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
330617 1433670 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Premorbid effects of APOE on synaptic proteins in human temporal neocortex
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Premorbid effects of APOE on synaptic proteins in human temporal neocortex
چکیده انگلیسی

APOE affects the risk of Alzheimer's disease (AD) and course of several other neurologic diseases. Experimental studies suggest that APOE influences synaptogenesis. We measured the concentration of two presynaptic proteins, synaptophysin and syntaxin 1, and also postsynaptic density-95 (PSD95), in superior temporal cortex from 42 AD and 160 normal brains, and determined the APOE genotypes. The concentration of both presynaptic proteins was approximately two-thirds lower in AD than normal brains and that of PSD95 one-third lower. No effect of APOE on synaptic proteins was found in advanced AD. However, in normal brain, ɛ4 was associated with lower concentrations of all three synaptic proteins and ɛ2 with significantly elevated PSD95 (p = 0.03). A combined measure of synaptic proteins showed a significant linear decrease from ɛ2 through ɛ3 to ɛ4 (p = 0.01). APOE influences the concentration of synaptic proteins in normal superior temporal cortex and may thereby affect the response to injury, and the risk and outcome of a range of neurologic diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 27, Issue 6, June 2006, Pages 797–803
نویسندگان
, , , , , ,