کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3306531 1210370 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nafamostat mesylate in the prevention of post-ERCP pancreatitis and risk factors for post-ERCP pancreatitis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
Nafamostat mesylate in the prevention of post-ERCP pancreatitis and risk factors for post-ERCP pancreatitis
چکیده انگلیسی

BackgroundPancreatitis is a major complication of ERCP.ObjectiveTo determine whether nafamostat mesylate prophylaxis decreases the incidence of post-ERCP pancreatitis (PEP).DesignA single-center, randomized, double-blinded, controlled trial.SettingA large tertiary-referral center.PatientsFrom January 2005 to December 2007, a total of 704 patients who underwent ERCP were analyzed.InterventionPatients received continuous infusion of 500 mL of 5% dextrose solution with 20 mg of nafamostat mesylate (354 patients) or without 20 mg of nafamostat mesylate (350 patients). Serum amylase and lipase levels were checked before ERCP, 4 and 24 hours after ERCP, and when clinically indicated.Main Outcome MeasurementsThe incidence of PEP and risk factors associated with the development of PEP.ResultsThe incidence of acute pancreatitis was 5.4%. There was a significant difference in the incidence of PEP between the nafamostat mesylate and control groups (3.3% vs 7.4%, respectively; P = .018). Univariate analysis identified history of acute pancreatitis (P < .001), difficult cannulation (P = .023), periampullary diverticulum (P = .004), age younger than 40 years (P = .009), and ≥5 pancreatic-duct contrast injections (odds ratio [OR] 2.736, P = .012) as statistically significant risk factors.LimitationsA single-center study.ConclusionsNafamostat mesylate prophylaxis is partially effective in preventing post-ERCP pancreatitis. Independent risk factors for PEP are a history of acute pancreatitis and multiple pancreatic-duct contrast injections.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastrointestinal Endoscopy - Volume 69, Issue 4, April 2009, Pages e11–e18
نویسندگان
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