کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
330654 1433675 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Insulin effects on CSF norepinephrine and cognition in Alzheimer's disease
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Insulin effects on CSF norepinephrine and cognition in Alzheimer's disease
چکیده انگلیسی

We assessed the effects of induced hyperinsulinemia on plasma and cerebrospinal fluid (CSF) levels of norepinephrine (NE) and on cognition for patients with Alzheimer's disease (AD) and normal older adults. For normal adults, insulin increased plasma and CSF NE levels; also, recall for paraphrased details of a story improved as CSF NE levels increased. Mental control was positively correlated with CSF levels of NE for patients. These findings demonstrate that raising peripheral insulin levels can modulate CNS NE levels and suggest that insulin-stimulated increases in NE may modulate cognitive functions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 27, Issue 1, January 2006, Pages 38–41
نویسندگان
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