کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3306577 1210371 2010 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prevalence and risk of colorectal neoplasms in asymptomatic, average-risk screenees 40 to 49 years of age
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
Prevalence and risk of colorectal neoplasms in asymptomatic, average-risk screenees 40 to 49 years of age
چکیده انگلیسی

BackgroundA paucity of information exists regarding colorectal neoplasm in asymptomatic, average-risk individuals 40 to 49 years of age.ObjectiveTo evaluate the prevalence and risk factors of colorectal neoplasms in those in their 40s.DesignCross-sectional study.SettingResults offered to subjects of a health care provider that offers screening services as part of an employer-provided wellness program.PatientsA consecutive series of 1761 asymptomatic, average-risk screenees 40 to 59 years of age.InterventionFirst screening colonoscopy.ResultsThe prevalence of overall colorectal neoplasm in subjects of ages 40 to 44 years, 45 to 49 years, 50 to 54 years, and 55 to 59 years increased significantly with increasing age (13.7%, 20.2%, 21.0%, and 23.8%, respectively; P < .001). The prevalence of advanced adenomas in subjects of ages 40 to 44 years, 45 to 49 years, 50 to 54 years, and 55 to 59 years increased significantly with age (1.9%, 3.0%, 3.2%, and 5.9%, respectively; P = .004). Multivariate analysis of data from the 40- to 49-year age group identified an increased risk of colorectal neoplasm associated with ages 45 years and older (odds ratio [OR], 1.68; 95% CI, 1.20-2.35), male sex (OR, 1.76; 95% CI, 1.15-2.69), presence of abdominal obesity (OR, 1.57; 95% CI, 1.12-2.21), and metabolic syndrome (OR, 1.56; 95% CI, 1.03-2.35), whereas for advanced adenomas, abdominal obesity (OR, 2.37; 95% CI, 1.06-5.27) and metabolic syndrome (OR, 2.83; 95% CI, 1.23-6.53) were the independent risk factors.LimitationsSingle-center study and the cohort composed of ethnic Korean subjects who lived in the same geographic region.ConclusionIn average-risk individuals 40 to 49 years of age, men with abdominal obesity or metabolic syndrome might benefit from screening colonoscopy starting at 45 years of age to detect colorectal neoplasm.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastrointestinal Endoscopy - Volume 72, Issue 3, September 2010, Pages 480–489
نویسندگان
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