کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3311431 | 1210862 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Relationship between in vivo chlorzoxazone hydroxylation, hepatic cytochrome P450 2E1 content and liver injury in obese non-alcoholic fatty liver disease patients
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کلمات کلیدی
CLZCYP2E1NAFLDROS - ROSSteatohepatitis - استاتو هپاتیتnon-alcoholic fatty liver disease - بیماری کبدی چربی غیر الکلیSteatosis - تغییر چرب یا استئاتوز cytochrome P450 2E1 - سیتوکروم P450 2E1body mass index - شاخص توده بدنBMI - شاخص توده بدنیObesity - مرض چاقیChlorzoxazone - کلرزوکسازونReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The study groups were obese women with an average body mass index (BMI) of 40.3Â kg/m2, who underwent therapeutic gastroplasty or gastrectomy with a gastro-jejunal anastomosis. Further, the hepatic histology was determined to establish the pathological score grouping the subjects into three categories: control, steatosis and steatohepatitis. The liver CYP2E1 content and the CLZ hydroxylation of obese patients with steatosis and, particularly, with steatohepatitis were significantly higher than controls and correlated positively with both the severity of the liver damage. These data provide evidence that CYP2E1 would be involved in the mechanism of liver injury found in obese NAFLD patients. Also, the correlation between liver CYP2E1 content and in vivo CLZ hydroxylation would validate the latter as a reliable indicator of liver injury in NAFLD, thus providing a simple and not invasive method to study these patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hepatology Research - Volume 34, Issue 1, January 2006, Pages 57-63
Journal: Hepatology Research - Volume 34, Issue 1, January 2006, Pages 57-63
نویسندگان
Myriam Orellana, Ramón Rodrigo, Nelson Varela, Julia Araya, Jaime Poniachik, Attila Csendes, Gladys Smok, Luis A. Videla,