کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
331201 1433640 2008 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Functional connectivity of the hippocampus in elderly with mild memory dysfunction carrying the APOE ɛ4 allele
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Functional connectivity of the hippocampus in elderly with mild memory dysfunction carrying the APOE ɛ4 allele
چکیده انگلیسی

The purpose of the present study was to evaluate functional connectivity of the hippocampus during a fMRI face–name learning task in a group of elders with mild memory impairment on the basis of the presence or absence of the APOE ɛ4 allele. Twelve ɛ4 carriers and 20 non-carriers with mild memory dysfunction and exhibiting equivalent performance in clinical evaluations of global cognitive function and memory were studied. Subjects underwent a fMRI session consisting of a face–name encoding memory task. Following scanning, subjects were asked to pair faces with their corresponding proper name. Functional connectivity of the hippocampus was measured by using coherence analysis to evaluate the activity of brain circuits related to memory encoding processes. In contrast to non-APOE ɛ4 allele bearers, APOE ɛ4 carriers showed enhanced connectivity with the anterior cingulate, inferior parietal/postcentral gyrus region and the caudate nucleus. Enhanced hippocampal connectivity with additional brain regions in APOE ɛ4 allele carriers during the performance of an associative memory task may reveal the existence of additional activity in the cortico-subcortical network engaged during memory encoding in subjects carrying this genetic variant.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 29, Issue 11, November 2008, Pages 1644–1653
نویسندگان
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