کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3315595 1211278 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hepatocellular adenoma displaying a HNF1α inactivation in a patient with familial adenomatous polyposis coli
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
Hepatocellular adenoma displaying a HNF1α inactivation in a patient with familial adenomatous polyposis coli
چکیده انگلیسی

Patients with familial adenomatous polyposis coli (FAP) may rarely develop hepatocellular adenoma. Here we report the case of a 37-year-old FAP woman presenting a hepatocellular adenoma after oestroprogestative oral contraception use. In this steatotic adenoma, we identified an inactivating biallelic mutation of HNF1α. In addition to the known germline APC mutation Q1062fs, we did not find an inactivation of the second APC allele nor an activation of the β-catenin target genes GLUL and GPR49. Our findings contrast with two hepatocellular adenoma cases related to FAP, for which a biallelic inactivation of the APC gene was previously described. Altogether, these results suggest that benign hepatocellular carcinogenesis may be dependent on or independent of the Wnt/β-catenin pathway in patients with FAP.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hepatology - Volume 45, Issue 6, December 2006, Pages 883–886
نویسندگان
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