Long-term in vitro culture of hamster pancreatic β-cells and induction of adenocarcinoma by treatment with N-nitrosobis(2-oxopropyl)amine

Pancreatic β-cells are the primary target of BOP without necessarily being embedded in the compound of the Langerhans' islet. With time in culture, they give rise to undifferentiated cells and after malignant transformation they are able to form ductal adenocarcinoma.