Transient splenial lesion in patient with malignant neuroleptic syndrome

A 23-year-old woman presented with abnormal behavior and hallucinations. She has received continuous treatment for bipolar disorder over the last two years. Within 7 days of the onset of symptoms the patient became catatonic, with hyperthermia up to 41 °C. The brain MRI showed high signal intensity on the T2-weighted and FLAIR sequences in the splenium of the corpus callosum (SCC). A second MRI two weeks later showed a complete resolution of SCC lesion. The patient was given a course of electroconvulsive therapy and recovered completely from her neurological symptoms in two months after the onset of symptoms. Reversible corpus callosum syndrome in patients with catatonia should be considered in differential diagnosis.