کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3318201 1211589 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Role of Phosphatidylinositol 3-Kinase Signaling Pathways in Pancreatic Cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
The Role of Phosphatidylinositol 3-Kinase Signaling Pathways in Pancreatic Cancer
چکیده انگلیسی
Background: Pancreatic cancer is a highly malignant cancer and the fourth leading cause of cancer-related death. It is characterized by a rapid disease progression, a highly invasive tumor phenotype, and frequently resistance to chemotherapy. Despite significant advances in diagnosis, staging, and surgical management of the disease during the past decade, prognosis of pancreatic cancer is still dismal. Methods and Results: The phosphatidylinositol 3-kinase (PI3K) signaling pathways regulate cellular growth, metabolism, survival, and motility in pancreatic cancer. Pancreatic cancer is associated with a high degree of genetic alterations that can result in aberrant activation of the PI3K signaling pathway. Elucidating the role of the PI3K signaling pathway in pancreatic cancer may thus be both meaningful and necessary. Conclusion: Improved knowledge of the PI3K signaling pathway in pancreatic cancer would furthermore be helpful in understanding mechanisms of tumor initiation and progression, and in identifying appropriate targeted anticancer treatment in pancreatic cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pancreatology - Volume 11, Issue 2, August 2011, Pages 252-260
نویسندگان
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