کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3318387 | 1211599 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pancreatic Calcium Signaling: Role in Health and Disease
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
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چکیده انگلیسی
In order to control cell functions, extracellular agents, such as hormones or neurotransmitters among others, generate a diversity of calcium (Ca2+) signals in target cells. Here, we review the components involved in Ca2+ handling and effectors, both members of the known calcium signaling pathways. In the pancreas, Ca2+ signal appears as local increases, global elevations or Ca2+ oscillations. Ca2+ plays a key role in the pancreatic cells, regulating secretion in exocrine cells, a widely used model for studying the coupling between Ca2+ signaling and secretion, and the release of insulin, glucagon and somatostatin in the exocrine pancreas. Interestingly, Ca2+ deregulations have been related to pancreatitis and aging of the pancreas, and treatment with melatonin has shown beneficial effects suggesting that melatonin could be an adequate therapeutic approach.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pancreatology - Volume 9, Issue 4, June 2009, Pages 329-333
Journal: Pancreatology - Volume 9, Issue 4, June 2009, Pages 329-333
نویسندگان
Pedro J. Gomez-Pinilla, Pedro J. Camello, MarÃa J. Pozo,