کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3318433 | 1211601 | 2006 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chronic pancreatitis: Evolving paradigms
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کلمات کلیدی
interleukin - اینترلوکینtransforming growth factor-β - تبدیل فاکتور رشد βtumor necrosis factor-α - تومور نکروز عامل αpancreatic stellate cell - سلول ستون لوزالمعدهproinflammatory cytokines - سیتوکین های ضد التهابیplatelet-derived growth factor - فاکتور رشد حاصل از پلاکتchronic pancreatitis - پانکراتیت مزمن
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Chronic pancreatitis (CP) is characterized by progressive fibrosis, pain and/or loss of exocrine and endocrine functions. With the identification and characterization of pancreatic stellate cells (PSCs), the pathogenesis of CP and pancreatic fibrosis is now better understood. Molecular mediators shown to regulate the pathogenesis include transforming growth factor-β, platelet-derived growth factor, and proinflammatory cytokines such as interleukin (IL)-1, IL-6 and tumor necrosis factor-α. Besides these, the roles of cyclooxygenase (COX)-2 and apoptosis-related proteins have also been implicated in the pathogenesis. Furthermore, molecular pathways involving mitogen-activated protein kinases, phosphatidylinositol 3-kinase, Ras superfamily G proteins, serine threonine protein kinase Raf-1 and peroxisome proliferator-activated receptor-γ (PPAR-γ) have been elucidated. Newer pathobiologic concepts concerning pain generation have also been put forward. Understanding the pathogenesis has led to the identification of novel molecular targets and the development of newer potential therapeutic agents. Those found to retard the progression of experimental CP and fibrosis in animal models include antioxidants, a Japanese herbal medicine called Saiko-keisi-to (TJ 10), the PPAR-γ ligand troglitazone, the protease inhibitor Camostat mesilate, and Lovastatin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pancreatology - Volume 6, Issue 5, October 2006, Pages 440-449
Journal: Pancreatology - Volume 6, Issue 5, October 2006, Pages 440-449
نویسندگان
Rupjyoti Talukdar, Nripen Saikia, Dinesh Kumar Singal, Rakesh Tandon,