کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3318453 | 1211602 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Clinicopathological Features of Patients with Concomitant Intraductal Papillary Mucinous Neoplasm of the Pancreas and Pancreatic Endocrine Neoplasm
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
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چکیده انگلیسی
Background/Aims: The occurrence of concomitant pancre- atic endocrine neoplasm (PEN) and intraductal papillary neoplasm (IPMN) of the pancreas has rarely been reported. We describe our experience with 3 patients with this association and review the existing literature. Methods: From 1990 to 200565 ? patients who underwent surgery for a PEN or IPMN were retrospectively reviewed. Forty-three patients had a PEN19 ? had an IPMN and 3 had both an IPMN and PEN. The 3 patients with concomitant IPMN and PEN are the focus of the current study and their clinicopathological features are reported together with 7 patients previously reported in the literature.Results: There were 10 patients with a median age of 62 years (range 40-73). The male:female ratio was equal. Seven of 10 patients were symptomatic and the most common symptoms were abdominal pain (n = 5)? jaundice (n = 2) and loss of weight (n = 2). The median size of the endocrine neoplasms was 14 mm (range 2-30) and they occurred in the head (n = 3)? body (n = 2) and tail (n = 5). Seven of the PENs were classified as benign2 ? were potentially malignant? and 1 was frankly malignant with lymph node involvement. None of the endocrine neoplasms were functioning. The IPMNs were found in the tail (n = 4)? head (n = 3)? head and body (n = 1)? body (n = 1) and the entire pancreas (n = 1). Five of these neoplasms were benign2 ? were borderline and 3 were malignant (1 carcinoma in situ).Conclusion: The occurrence of concomitant IPMN and PEN is more frequent than would be expected. However? it is difficult in the present analysis to determine if this association is more than just fortuitous.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pancreatology - Volume 6, Issue 6, 2006, Pages 520-526
Journal: Pancreatology - Volume 6, Issue 6, 2006, Pages 520-526
نویسندگان
Brian K.P. Goh, London L.P.J. Ooi, Marian Priyanthi Kumarasinghe, Yu-Meng Tan, Chung Peng-Cheow, Pierce K.H. Chow, Fui Yaw-Alexander Chung, Keong Wai-Wong,