کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3332272 1590929 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genetic diagnosis of seronegative (HIV−) partner of female patient with AIDS in the context of HIV transmission
ترجمه فارسی عنوان
تشخیص ژنتیکی شریک سرم منفی (اچ آی وی منفی) بیمار زن مبتلا به ایدز در زمینه انتقال اچ آی وی
کلمات کلیدی
CCR5-Δ32؛ انتقال اچ آی وی. HLA-B؛ گیرنده های سلول های کشنده ایمونوگلوبولین مانند
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی

AimComplex genetic diagnosis of seronegative (HIV−) long-term partner of female patient with AIDS C3 in the context of HIV transmission. Case report and literature review.BackgroundHIV infection was excluded in 47-year-old man, a long-term sexual partner of female patient diagnosed with AIDS C3. The risk of HIV infection was estimated as high.ObjectiveWe focused on the genetic diagnosis of serodiscordant couple. We determined the presence of CCR5-Δ32, CCR2-64I, HLA-B, killer cell immunoglobulin-like receptor (KIR) and their ligand genes and human endogenous retroviruses K113 and K115.MethodsGenotyping was performed using PCR methods.ResultsAnalysis of partner's genotype revealed the presence of CCR5-Δ32/Δ32 and KIR genes encoding activating receptors (KIR2DS1, 2DS5, 3DS1), features associated with reduced risk of HIV transmission. Similarities in patient's and her partner's HLA (HLA-B*51) and similar inhibitory KIR repertoire and their ligands (KIR2DL1+HLA-C2, KIR2DL3+HLA-C1, KIR3DL1+HLA-B Bw4-80Ile) could favor the transmission of the virus.ConclusionGenetic diagnosis is not routinely recommended, observation of exposed and uninfected individuals would allow to implement new knowledge into more effective care.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: HIV & AIDS Review - Volume 15, Issue 2, 2016, Pages 97–100
نویسندگان
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