Post renal transplant acute kidney injury

AKI specific to the renal transplant includes ischemia-reperfusion injury, acute rejection, acute calcineurin inhibitor (CNI) toxicity, venous or arterial thrombosis, urinary tract obstruction, graft pyelonephritis and recurrent disease. The graft is more susceptible to hemodynamic insults as it is denervated and there is at least partial loss of its autoregulatory capacity. Some factors unrelated to the transplant like sepsis may also predispose AKI in post-transplant period. The article particularly highlights the issues of AKI other than acute rejections.