کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3338902 1213895 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Patients with Diabetes Mellitus are Prone to Develop Severe Hepatitis and Liver Failure due to Hepatitis Virus Infection
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کبدشناسی
پیش نمایش صفحه اول مقاله
Patients with Diabetes Mellitus are Prone to Develop Severe Hepatitis and Liver Failure due to Hepatitis Virus Infection
چکیده انگلیسی

BackgroundAcute viral hepatitis (AVH) is usually a self-limiting illness. Diabetics are prone to develop liver diseases and liver regeneration is impaired in them. Natural course of AVH in diabetics has not been assessed and may be severe.DesignObservational prospective study to evaluate natural course of AVH in patients with and without diabetes mellitus. Consecutive patients with AVH were included and categorized in to those with or without diabetes. Etiology, complications, mortality and recovery parameters of AVH were identified and compared between two groups.Results131 consecutive AVH between March 2007 and March 2009 were evaluated; 12 diabetics and 83 non-diabetics (n = 95) were included for analysis. Hepatitis E was the commonest cause (n = 55, 57.89%) in the whole cohort. However, Hepatitis B virus (HBV) as the etiology was significantly higher among diabetics than in non-diabetics (58.33% vs. 25.3%, P = 0.02). In contrast, hepatitis E was the etiology in 61.44% of non-diabetics. Frequency of severe hepatitis was significantly higher in diabetics than in non-diabetics (5/12; 41.67% vs. 9/83; 10.64%, P < 0.005). 5 of 14 (36%) with severe hepatitis were diabetics. Liver failure and death occurred in 2 (16%) diabetics, while none among the non-diabetics had liver failure. Multiple variable logistic regression analysis revealed that acute hepatitis B (OR 4.7 (95% CI 1.34–16.47)) and diabetes (OR 4.0 (95% CI 0.96–16.47)) were associated with severe hepatitis.ConclusionPatients with diabetes are at risk to contact HBV infection and severe hepatitis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical and Experimental Hepatology - Volume 3, Issue 4, December 2013, Pages 275–280
نویسندگان
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