کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3343815 1591187 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Rare severe mycotic infections in children receiving empirical caspofungin treatment for febrile neutropenia
ترجمه فارسی عنوان
عفونت های شدید ملودی شدید در کودکان مبتلا به کاسپوفونژین تجربی برای نوتروپنی تب
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی و میکروب شناسی (عمومی)
چکیده انگلیسی

Empirical antifungal therapy is most often given to patients with leukemia. However breakthrough fungal infections under antifungal therapy are not uncommon. Four children, with hematologic malignant disease developed mycotic breakthrough infections while on empirical caspofungin treatment for a median of 14 (range 11–19) days. Trichosporon asahii was detected in the blood culture of two patients and Geotrichum capitatum in the other two (one patient also had positive cerebrospinal fluid culture). Because the patients’ clinical situation worsened, voriconazole was empirically added for two patients three and five days before the agent was detected. The first sterile blood culture was obtained 3–7 days of voriconazole treatment. All patients reached clear cultures but one patient died. One patient with central nervous system infection with G. capitatum had severe neurological sequelae. Very severe fungal infections can occur during empirical caspofungin therapy. Therefore, patients should be followed closely.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Brazilian Journal of Infectious Diseases - Volume 19, Issue 5, September–October 2015, Pages 549–552
نویسندگان
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