کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3344052 | 1591201 | 2013 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Strategies to reduce mortality and morbidity due to AIDS-related cryptococcal meningitis in Latin America Strategies to reduce mortality and morbidity due to AIDS-related cryptococcal meningitis in Latin America](/preview/png/3344052.png)
Latin America is the region with the third most AIDS-related cryptococcal meningitis infections globally. Highly active antiretroviral therapy (HAART) has reduced the number of infections; however, the number of deaths and the case-fatality rate continues to be unacceptable. In this review, we focus on the burden of AIDS-related cryptococcosis in Latin America and discuss potential strategies to reduce early mortality from Cryptococcus. In this review, we highlight the importance of: (1) earlier HIV diagnosis and HAART initiation with retention-in-care to avoid AIDS; (2) pre-HAART cryptococcal antigen (CRAG) screening with preemptive fluconazole treatment; (3) better diagnostics (e.g. CRAG testing); and (4) optimal treatment with aggressive management of intracranial pressure and induction therapy with antifungal combination. Implementation of these strategies can reduce cryptococcal-related deaths, improve care, and reduce healthcare costs.
Journal: The Brazilian Journal of Infectious Diseases - Volume 17, Issue 3, May–June 2013, Pages 353–362