کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3344546 | 1591212 | 2011 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Successful treatment of pulmonary Nocardia farcinica infection with linezolid: case report and literature review Successful treatment of pulmonary Nocardia farcinica infection with linezolid: case report and literature review](/preview/png/3344546.png)
Nocardia infection is rare but potentially fatal. Therapy of Nocardia infection remains difficult. Linezolid, a novel oxazolidinone antibiotic, has proven to be effective, but clinical data are limited. Here we describe a case of a 45-year-old man with pulmonary N. farcinica infection following a liver transplantation. The initial therapy was trimethoprim-sulfamethoxazole, which showed no effect. According to susceptibility test, linezolid was administered with clearly improving the patient's condition. The treatment was stopped for anemia as drug related adverse event, and the therapy lasted for as long as 5 months. At the end of treatment clinical cure was confirmed and anemia reversed after discontinuation of linezolid. We also analyzed the clinical data of previously published reports by literature review, focusing on the efficacy and safety of linezolid treatment for Nocardia infection.
Journal: The Brazilian Journal of Infectious Diseases - Volume 15, Issue 5, September–October 2011, Pages 486-489