کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
334498 546565 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prefrontal hyperactivation during a working memory task in early-onset schizophrenia spectrum disorders: An fMRI study
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Prefrontal hyperactivation during a working memory task in early-onset schizophrenia spectrum disorders: An fMRI study
چکیده انگلیسی

Working memory (WM) dysfunction is increasingly recognized as a core feature of schizophrenia, but few studies have investigated prefrontal activation during WM tasks in early-onset schizophrenia spectrum disorder (EOS). Our aim was to explore prefrontal activation during a WM-task in EOS patients compared to healthy controls using functional magnetic resonance imaging (fMRI). Fifteen patients with EOS and 15 matched healthy controls performed a 0-back and a 2-back task while fMRI data were acquired. Results indicated that even though performance between patients and controls was comparable on both tasks, there was a hyperactivation in patients' ventrolateral prefrontal cortex (VLPFC) during the 2-back task compared to healthy controls. This pattern of activation suggests that, in patients with EOS, the VLPFC compensated in order to match performance of the controls. The activations in the EOS group may reflect the use of a compensatory, cognitive strategy while solving WM-tasks.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 194, Issue 3, 30 December 2011, Pages 257–262
نویسندگان
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