کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
334550 546580 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Influence of work shift on glutamic acid and gamma-aminobutyric acid (GABA): Evaluation with proton magnetic resonance spectroscopy at 3T
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Influence of work shift on glutamic acid and gamma-aminobutyric acid (GABA): Evaluation with proton magnetic resonance spectroscopy at 3T
چکیده انگلیسی

Working conditions such as shift work constitute a well-known risk factor for insomnia and excessive daytime sleepiness complaints. We compared brain gamma-aminobutyric acid (GABA), glutamic acid (Glu), glutamine (Gln), and Glx (Glu+Gln) levels in day-shift versus alternate-shift workers with proton magnetic resonance spectroscopy (1H-MRS) at 3T. The study population consisted of 32 healthy adult volunteers (16 day-shift and 16 alternate-shift workers). Each subject underwent MRS conducted using a MEGA-PRESS sequence in the early morning and early evening on the same day. Spectroscopy voxels (3.0 cm × 3.0 cm × 3.0 cm) were placed in the frontal lobe and parieto-occipital lobe. The GABA/Cr ratio in the frontal lobe was significantly lower for the alternate-shift group than for the day-shift group in the early evening (1.885 vs. 0.875). For the other metabolite ratios (Gln/Cr and Glx/Cr), there were no significant differences between the two groups regardless of morning or evening schedule. Our preliminary finding represents a possible alteration of GABA content in the brain related to an irregular work schedule.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 192, Issue 1, 30 April 2011, Pages 55–59
نویسندگان
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