کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
334651 546617 2007 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Thalamo-cortical dysfunction in cocaine abusers: Implications in attention and perception
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Thalamo-cortical dysfunction in cocaine abusers: Implications in attention and perception
چکیده انگلیسی

Cocaine affects sensory perception and attention, but little is known about the neural substrates underlying these effects in the human brain. We used functional magnetic resonance imaging (fMRI) and a sustained visuospatial attention task to assess if the visual attention network is dysfunctional in cocaine abusers (n = 14) compared to age-, gender-, and education-matched controls (n = 14). Compared with controls, cocaine abusers showed (1) hypo-activation of the thalamus, which may reflect noradrenergic and/or dopaminergic deficits; (2) hyper-activation in occipital and prefrontal cortices, which may reflect increased visual cortical processing to compensate for inefficient visual thalamic processing; and (3) larger deactivation of parietal and frontal regions possibly to support the larger hemodynamic supply to the hyper-activated brain regions. These findings provide evidence of abnormalities in thalamo-cortical responses in cocaine abusers that are likely to contribute to the impairments in sensory processing and in attention. The development of therapies that diminish these thalamo-cortical deficits could improve the treatment of cocaine addiction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 155, Issue 3, 15 August 2007, Pages 189–201
نویسندگان
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