کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3346763 | 1407783 | 2016 | 6 صفحه PDF | دانلود رایگان |
• Caspofungin exhibits a significant and prolonged postantifungal effect against Candida albicans clade.
• Postantifungal effect against Candida albicans clade is significantly higher than for Candida parapsilosis clade.
• Caspofungin was fungicidal against Candida albicans, Candida dubliniensis and Candida metapsilosis.
Killing and postantifungal effects could be relevant for the selection of optimal dosing schedules. This study aims to compare time-kill and postantifungal effects with caspofungin on Candida albicans (C. albicans, Candida dubliniensis, Candida africana) and Candida parapsilosis (C. parapsilosis, Candida metapsilosis, Candida orthopsilosis) clades. In the postantifungal effect experiments, strains were exposed to caspofungin for 1 h at concentrations 0.12–8 μg/mL. Time-kill experiments were conducted at the same concentrations. Caspofungin exhibited a significant and prolonged postantifungal effect (>37 h) with 2 μg/mL against the most strains of C. albicans clade. Against the C. parapsilosis clade, the postantifungal effect was <12 h at 8 μg/mL, except for two strains. Caspofungin was fungicidal against C. albicans, C. dubliniensis and C. metapsilosis.
Journal: Diagnostic Microbiology and Infectious Disease - Volume 86, Issue 2, October 2016, Pages 172–177