کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
334716 546653 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Psychomotor symptoms of schizophrenia map on the cerebral motor circuit
ترجمه فارسی عنوان
علائم روانشناختی اسکیزوفرنی بر روی مدار مغزی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی


• Schizophrenia is associated with aberrant motor behavior.
• Motor behavior maps on the cerebral motor system.
• Evidence is strong for neurological soft signs and motor retardation.
• Evidence on catatonia and parkinsonism is scarce.

Schizophrenia is a devastating disorder thought to result mainly from cerebral pathology. Neuroimaging studies have provided a wealth of findings of brain dysfunction in schizophrenia. However, we are still far from understanding how particular symptoms can result from aberrant brain function. In this context, the high prevalence of motor symptoms in schizophrenia such as catatonia, neurological soft signs, parkinsonism, and abnormal involuntary movements is of particular interest. Here, the neuroimaging correlates of these motor symptoms are reviewed. For all investigated motor symptoms, neural correlates were found within the cerebral motor system. However, only a limited set of results exists for hypokinesia and neurological soft signs, while catatonia, abnormal involuntary movements and parkinsonian signs still remain understudied with neuroimaging methods. Soft signs have been associated with altered brain structure and function in cortical premotor and motor areas as well as cerebellum and thalamus. Hypokinesia is suggested to result from insufficient interaction of thalamocortical loops within the motor system. Future studies are needed to address the neural correlates of motor abnormalities in prodromal states, changes during the course of the illness, and the specific pathophysiology of catatonia, dyskinesia and parkinsonism in schizophrenia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 233, Issue 3, 30 September 2015, Pages 293–298
نویسندگان
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