کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3347281 1215959 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Helicobacter pylori oipA genetic diversity and its associations with both disease and cagA, vacA s, m, and i alleles among Bulgarian patients
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Helicobacter pylori oipA genetic diversity and its associations with both disease and cagA, vacA s, m, and i alleles among Bulgarian patients
چکیده انگلیسی

Prevalence of outer inflammatory protein (oipA) gene functional status in Helicobacter pylori strains from Southeastern Europe is still unclear. H. pylori strains from 70 symptomatic patients were polymerase chain reaction (PCR) assessed for cagA and vacA types, and oipA gene functional status was evaluated by PCR and sequencing. Our results demonstrated a high prevalence of strains with oipA status “on” genes (81%) and strong association between them and peptic ulcers, cagA, and vacA s1 and s1/m1 genotypes, regardless of the patient gender, place of residence, and age. Importantly, most vacA i1 strains (93%) harbored oipA status “on” versus only 57% of those with vacA i2 type. The vacA i1 genotype was less frequent (66%) than both cagA and vacA s1 types. The virulent strains with cagA+ and vacA s1, m1, and i1 were detected in 35% as a predominant genotype and almost all (96%) of these strains harbored oipA status “on”. In conclusion, the high prevalence of in-frame oipA gene strains (81%), associated with peptic ulcers and cagA+, vacA s1, m1, m2, and, importantly, i1 genotypes, indicates a strong synergistic activity of H. pylori virulence factors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diagnostic Microbiology and Infectious Disease - Volume 71, Issue 4, December 2011, Pages 335–340
نویسندگان
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