کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
334744 546660 2014 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Resting state networks in major depressive disorder
ترجمه فارسی عنوان
استراحت در شبکه های دولتی در اختلال افسردگی عمده
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی


• Regions of the default mode and salience networks are consistently affected by major depressive disorder.
• There are interesting findings in the cerebellum, lingual gyrus, anterior cingulate cortex, middle frontal gyrus, dorsolateral prefrontal cortex, amygdala and insula.
• There are few studies examining the effects of antidepressants on resting state fMRI.

Resting state functional magnetic resonance imaging (fMRI) examines the spontaneous low frequency neural activity of the brain to reveal networks of correlated neural activity. A number of different methodologies, each with its own advantages and disadvantages, have been used to examine networks of neural activity that may be related to clinical presentation. Major depressive disorder (MDD) research has largely focused on the default mode network (DMN), which is most active at rest and may relate to negative rumination. However, other networks can be discerned in the resting state such as salience and affective and cognitive control networks, all of which may be relevant to MDD psychopathology. This article reviews the rapidly increasing literature on resting state networks. A number of state- and trait-dependent abnormalities have been reported in MDD in a wide variety of regions including the cerebellum, lingual gyrus, anterior cingulate cortex (ACC), middle frontal gyrus (MFG), dorsolateral prefrontal cortex (dlPFC), amygdala and insula. Current and chronic medication is often a potential confound. Few trials have examined the immediate or delayed effects of antidepressants on resting state networks. This article presents a novel approach to the analysis of drug effects, the identification of signatures of efficacy, and thus for drug development.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 224, Issue 3, 30 December 2014, Pages 139–151
نویسندگان
, , ,