Emergence of extended-spectrum β-lactamase and fluoroquinolone resistance genes among Irish multidrug-resistant isolates

This study sought to identify mechanisms behind resistance to third-generation cephalosporins and ciprofloxacin in Irish multidrug-resistant Enterobacteriaceae isolates. The most prevalent extended-spectrum β-lactamase genes identified were blaSHV-12 and blaCTX-M-15. These were associated with the fluoroquinolone resistance genes aac(6′)-IB-cr, qnrA, and qnrB, not previously reported in Irish isolates.