کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3348194 1216002 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inducible clindamycin resistance in Staphylococcus aureus isolates causing bacteremia at a university hospital in southern Taiwan
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Inducible clindamycin resistance in Staphylococcus aureus isolates causing bacteremia at a university hospital in southern Taiwan
چکیده انگلیسی

A major concern while prescribing clindamycin to treat infections caused by inducible macrolide, lincosamide, and group B streptogramin (iMLSB)-resistant strains is clinical therapy failure. In this study, we determined the prevalence, mechanism, and clonality of the iMLSB phenotype in oxacillin-resistant Staphylococcus aureus (ORSA) and oxacillin-susceptible S. aureus (OSSA). Among the 729 OSSA isolates collected from July 1995 to March 2006, 72 (10%) were clindamycin sensitive (Clis) and erythromycin resistant (Ermr), and 55 (8%) had the iMLSB phenotype. In the 709 ORSA isolates collected from January 1997 to March 2006, 31 (4%) were Clis and Ermr, and 29 (4%) isolates demonstrated the iMLSB phenotype. In OSSA, ermC was the predominant (51 of 55 isolates) genetic determinant responsible for the iMLSB phenotype, whereas in ORSA, ermA was predominant (27 of 29). Pulsed-field gel electrophoresis showed that 8 pulsed types (RA to RH) were present in ORSA isolates (n = 27), and pulsed type RC was predominant in 17 isolates with 5 identifiable subtypes (RC1 to RC5); this type was prevalent from November 1997 to June 2004. In the OSSA (n = 24) isolates, 14 different pulsed types (SA to SN) were identified, but none was predominant. These results indicate that the incidence of iMLSB resistance phenotype is higher in OSSA than ORSA in Taiwan, and the genetic determinants responsible for the iMLSB phenotype vary in OSSA and ORSA.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diagnostic Microbiology and Infectious Disease - Volume 58, Issue 2, June 2007, Pages 203–209
نویسندگان
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