کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
334931 546718 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Voxel-based morphometry study of the insular cortex in bipolar depression
ترجمه فارسی عنوان
بررسی مورفومتری مبتنی بر وکسل قشر ساحلی در افسردگی دو قطبی
کلمات کلیدی
افسردگی دوقطبی، تصویربرداری رزونانس مغناطیسی، انسولا، مورفومتری مبتنی بر وکسل
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی


• This is the first voxel-based morphometry study to examine bipolar depression.
• Bipolar depression patients had opposite volume changes in left anterior insula.
• Lithium’s effects are associated with larger volumes in insular subregions.
• Insular subregion may be related to neural mechanism of bipolar depression.

Bipolar depression (BD) is a common psychiatric illness characterized by deficits in emotional and cognitive processing. Abnormalities in the subregions of the insula are common findings in neuroanatomical studies of patients with bipolar disorder. However, the specific relationships between morphometric changes in specific insular subregions and the pathogenesis of BD are not clear. In this study, structural magnetic resonance imaging (MRI) was used to investigate gray matter volume abnormalities in the insular subregion in 27 patients with BD and in 27 age and sex-matched controls. Using DARTEL (diffeomorphic anatomical registration through exponentiated lie algebra) for voxel-based morphometry (VBM), we examined changes in regional gray matter volumes of the insula in patients with BD. As compared with healthy controls, the BD patients showed decreased gray matter volumes in the right posterior insula and left ventral anterior insula and increased gray matter volumes in the left dorsal anterior insula. Consistent with the emerging theory of insular interference as a contributor to emotional-cognitive dysregulation, the current findings suggest that the insular cortex may be involved in the neural substrates of BD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 224, Issue 2, 30 November 2014, Pages 89–95
نویسندگان
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