کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3349758 1216363 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regulatory B cell: New member of immunosuppressive cell club
ترجمه فارسی عنوان
سلول های تنظیم کننده سلولی: عضو جدید سلول های سرکوب کننده ایمنی بدن
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی

Historically, the pivotal role of B cells or B lymphocytes in immunity has been attributed to the production of antibodies. They were also demonstrated to present antigens to T cells and to secrete cytokines, thereby acting as positive regulators in immune responses. A series of studies on autoimmune diseases, however, led researchers to find a unique subset of B cells, later described as “regulatory B cells” (Bregs), that has the ability to suppress immune responses. Bregs occur not only in autoimmune diseases, but also in inflammation and transplantation. Furthermore, recently published literatures suggested that Bregs contributed to the growth and metastasis of certain cancers. In this review, we will discuss these unique subsets of B cells in different kinds of disorders, with particular emphasis on the mechanisms of their immunoregulatory role that were collected from mice and humans.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Immunology - Volume 76, Issue 9, September 2015, Pages 615–621
نویسندگان
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