کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3350195 1591377 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Co-signaling molecules in psoriasis pathogenesis: Implications for targeted therapy
ترجمه فارسی عنوان
مولکول های سیگنالینگ همراه در پاتوژنز پسوریازیس: پیامدهای درمان هدفمند
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی

Psoriasis is a T cell-dependent immune-mediated disease of the skin and joints. It is clear that co-stimulatory and co-inhibitory molecules (currently named co-signaling molecules collectively) synergize with TCR signaling to promote or inhibit T cell activation and function. In recent years, enthusiasm in the field of co-signaling research has been fueled by the success of co-stimulatory and co-inhibitory immunotherapy for the treatment of human diseases. This review outlines the involvement of several sets of co-signaling molecules in the immunopathogenesis of psoriasis. We then describe the relevant preclinical studies and summarize recent clinical findings on targeting these molecules for the treatment of psoriasis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Immunology - Volume 76, Issues 2–3, March 2015, Pages 95–101
نویسندگان
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