کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3350228 | 1216380 | 2012 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Human leukocyte antigen–G 3′ untranslated region polymorphisms are associated with better kidney allograft acceptance Human leukocyte antigen–G 3′ untranslated region polymorphisms are associated with better kidney allograft acceptance](/preview/png/3350228.png)
Human leukocyte antigen–G (HLA-G) plays a well-recognized role in the modulation of the immune response, and HLA-G expression has been associated with increased graft survival and decreased rejection episodes. To investigate the role of the HLA-G 3′ untranslated region (3′UTR) in renal transplantation, we evaluated several polymorphic sites (14-bp Del/Ins +3003T/C, +3010C/G, +3027C/A, +3035C/T, +3142G/C, and +3187A/G) in patients exhibiting or not exhibiting rejection episodes. A total of 104 patients (15 with acute and 48 with chronic rejection, and 41 with no rejection) and 142 healthy individuals were studied. HLA-G 3′UTR was typed by direct sequencing. The +3035C-C genotype was more frequent in patients exhibiting chronic rejection compared with healthy controls, and the +3035C-T genotype was less frequent in chronic rejection compared with patients without rejection (acute plus chronic) or compared with healthy controls. The +3187G-A genotype, in which the A allele is associated with increased mRNA degradation, showed increased frequency in the rejection group (acute plus chronic) when compared with healthy controls. The 14 base pair Deletion/Insertion genotype was marginally increased in patients with acute rejection. This is the first study to show associations among numerous polymorphic sites in the HLA-G 3′UTR in kidney allotransplantation, which may contribute to the understanding of HLA-G post-transcriptional mechanisms.
Journal: Human Immunology - Volume 73, Issue 1, January 2012, Pages 52–59