کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
335052 546757 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association of microstructural white matter abnormalities with cognitive dysfunction in geriatric patients with major depression
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Association of microstructural white matter abnormalities with cognitive dysfunction in geriatric patients with major depression
چکیده انگلیسی

Major depression disorder (MDD) is one of the most common causes of disability in people over 60 years of age. Previous studies have linked affective and cognitive symptoms of MDD to white matter (WM) disruption in limbic-cortical circuits. However, the relationship between clinical cognitive deficits and loss of integrity in particular WM tracts is poorly understood. Fractional anisotropy (FA) as a measure of WM integrity was investigated in 17 elderly MDD subjects in comparison with 18 age-matched controls using tract-based spatial statistics (TBSS) and correlated with clinical and cognitive parameters. MDD patients revealed significantly reduced FA in the right posterior cingulate cluster (PCC) compared with controls. FA in the right PCC (but not in the left PCC) showed a significant positive correlation with performance in a verbal naming task, and showed a non-significant trend toward a correlation with verbal fluency and episodic memory performance. In control subjects, no correlations were found between cognitive tasks and FA values either in the right or left PCC. Results provide additional evidence supporting the neuronal disconnection hypothesis in MDD and suggest that cognitive deficits are related to the loss of integrity in WM tracts associated with the disorder.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 203, Issues 2–3, August–September 2012, Pages 194–200
نویسندگان
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