کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3350726 1216404 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Analysis of the influence of two CD24 genetic variants in Crohn's disease and ulcerative colitis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Analysis of the influence of two CD24 genetic variants in Crohn's disease and ulcerative colitis
چکیده انگلیسی

The aim of this study was to evaluate the possible implication of CD24 gene in the genetic predisposition to inflammatory bowel disease (IBD). Our study population consisted of 1321 female Spanish individuals (369 Crohn's disease [CD] patients, 323 ulcerative colitis [UC] patients, and 629 healthy matched controls). Two putative functional polymorphisms, a C to T coding polymorphism (rs8734) and a TG deletion in the 3′ untranslated region (rs3838646), were used as CD24 genetic markers and genotyped using a Taqman 5′ allelic discrimination assay. The “del” allele of the dinucleotide deletion was associated with an increased risk of CD (odds ratio = 1.61, 95% confidence interval = 1.17–2.21, pFDR = 6.4E-03) but not with UC. Moreover, this allele was significant associated with the age of CD diagnosis between 17 and 40 years, the ileocolonic location, and the inflammatory behavior of CD. We observed no significant differences between the allelic or genotypic frequencies of the A57V polymorphism in our studied IBD cohort. Our results suggest that the rs3838646 CD24 polymorphism is part of the genetic background of CD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Immunology - Volume 72, Issue 10, October 2011, Pages 969–972
نویسندگان
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