کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3350942 | 1216410 | 2012 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Impact of infection or vaccination on pre-existing serological memory Impact of infection or vaccination on pre-existing serological memory](/preview/png/3350942.png)
Once established, serum antibody responses against a specific pathogen may last a lifetime. We describe a cohort of four subjects who received smallpox vaccination, and a single subject who received multiple vaccinations, with antibody levels to unrelated antigens monitored for 1–3 years. These immunizations provided the opportunity to determine if infection/vaccination and the resulting toll-like receptor stimulation would alter antigen-specific serological memory to other antigens, including bacterial toxins (tetanus, diphtheria, and pertussis) and viruses (yellow fever virus, measles, mumps, rubella, Epstein-Barr virus, and varicella-zoster virus). Our results indicate that serum IgG levels are remarkably stable and infection or vaccination are unlikely to increase or decrease pre-existing antigen-specific antibody responses.
Journal: Human Immunology - Volume 73, Issue 11, November 2012, Pages 1082–1086