کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3350949 | 1216410 | 2012 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Plasma myeloperoxidase levels correlate with hepatocellular carcinoma in chronic hepatitis C Plasma myeloperoxidase levels correlate with hepatocellular carcinoma in chronic hepatitis C](/preview/png/3350949.png)
Myeloperoxidase (MPO) is an enzyme responsible for generating hypochlorous acid and reactive oxidants that may lead to liver injury and cancer in hepatitis C (HCV) infection. MPO expression level is regulated by a polymorphism in the promoter region −463 of MPO gene. In the current study, MPO plasma levels and the G-463A MPO polymorphism were determined in 158 chronically HCV infected patients with and without hepatocellular carcinoma (HCC). MPO plasma levels were determined using a commercially ELISA kit. The G-463A MPO polymorphism was accessed by real time PCR using TaqMan probes. The MPO plasma levels of patients with HCV-HCC were higher in comparison to patients with chronic hepatitis or with those patients with severe fibrosis (p = 0.01 and p = 0.04, respectively). The MPO G-463A polymorphism was not associated with HCV outcome. These findings suggest MPO levels monitoring may be a potential biological marker to HCC screening in patients with HCV.
Journal: Human Immunology - Volume 73, Issue 11, November 2012, Pages 1127–1131