کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3351398 | 1216425 | 2009 | 4 صفحه PDF | دانلود رایگان |
Mannose-binding lectin (MBL) is a complement component and an opsonic factor recognizing and binding to herpes simplex virus 2 (HSV-2). In this study, we assessed the effect of MBL2 genotypes on the risk of recurring HSV-2 infection. The MBL2 structural variant genotype (A/O or O/O) was more common among the patients with recurrent HSV-2 infection compared with healthy controls (47% vs 26%, respectively; odds ratio [OR] = 2.6, 95% confidence interval [CI] 1.3–4.9; p = 0.005) or controls positive for HSV-2 antibodies (15%; OR 4.9, 95% CI 1.5–16; p = 0.007). Thus, we conclude that the MBL2 structural variant genotype, possibly through impaired recognition of HSV-2, seems to predispose individuals to the development of recurring HSV-2 infection.
Journal: Human Immunology - Volume 70, Issue 4, April 2009, Pages 218–221