کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3351401 | 1216425 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CRP/CD11b ratio: a novel parameter for detecting gram-positive sepsis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
To commence proper antibiotic treatment in sepsis, timely knowledge of whether the cause of systemic infection is gram-negative (gramâ) or gram-positive (gram+) bacteria in origin would be beneficial for clinicians. In this clinical prospective study, our objective was to develop a method for distinguishing between gram+ and gramâ bacterial infection. In gramâ bacterial infection (n = 21), the average amount of CD11b on neutrophils was significantly higher than in gram+ bacterial infection (n = 22). On the contrary, serum C-reactive protein (CRP) level was significantly higher in gram+ than in gramâ bacterial infection. By dividing the serum CRP value by the amount of CD11b on neutrophils, we derived a novel marker of gram+ sepsis, CRP/CD11b ratio, which displayed 76% sensitivity and 80% specificity for the detection of gram+ sepsis (n = 17) among febrile patients with microbiologically confirmed or clinically diagnosed bacterial infection. The detection of gram+ sepsis is possible after the combination of neutrophil CD11b data and serum CRP level. In conclusion, our findings indicate that the proposed CRP/CD11b ratio test could potentially assist physicians in determining an appropriate antibiotic treatment in patients with severe bacterial infection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Immunology - Volume 70, Issue 4, April 2009, Pages 237-243
Journal: Human Immunology - Volume 70, Issue 4, April 2009, Pages 237-243
نویسندگان
Jari Nuutila, Päivi Jalava-Karvinen, Ulla Hohenthal, Iina Laitinen, Pirkko Kotilainen, Allan Rajamäki, Jukka Nikoskelainen, Esa-Matti Lilius,