کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3351852 | 1216445 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sequence variations at the human leukocyte antigen-linked olfactory receptor cluster do not influence female preferences for male odors
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
We previously reported that paternally inherited human leukocyte antigen (HLA) alleles are a template for women's preferences for male odors (p = 0.0007). However, it has been suggested that sequence variation in a nearby olfactory receptor (OR) cluster on chromosome 6p influences smell preference. To determine whether the HLA-linked OR genes contribute to previously observed HLA-mediated behaviors, we use the odor preference data from our earlier study in combination with a new resequencing study of four functional, HLA-linked OR genes in the same subjects. Our results indicate that OR alleles in the genes surveyed are not in linkage disequilibrium with HLA variation and do not explain the previous findings of HLA-associated odor preference.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Immunology - Volume 71, Issue 1, January 2010, Pages 100-103
Journal: Human Immunology - Volume 71, Issue 1, January 2010, Pages 100-103
نویسندگان
Emma E. Thompson, Gabe Haller, Jayant M. Pinto, Ying Sun, Bethanne Zelano, Suma Jacob, Martha K. McClintock, Dan L. Nicolae, Carole Ober,